Day 44 of 280 · 6 weeks + 2 days
Before any pill
Last reviewed · 3 min read · 7 sources · Plain-text version
Vitamin B6 and an over-the-counter combination have real evidence behind them for nausea. Today you write the question for your provider before you try either.
- Size this week
- about the size and shape of a pea
- Length this week
- around 6 mm from head to bottom

Six weeks and two days. Yesterday was ginger. Today is the next step up, the one with a label on it, and the rule that comes before it.
Your baby

Your body
Vitamin B6 at 100 mg or less a day has been shown to ease morning sickness, and many providers suggest trying it first (MedlinePlus). Diclegis, a combination of doxylamine and vitamin B6, is FDA-approved for morning sickness (MedlinePlus); the same pairing, doxylamine (sold as Unisom) with B6, is described by MedlinePlus as very effective and safe for pregnancy nausea and available without a prescription (MedlinePlus). The Cochrane review is cooler: only limited evidence supports B6 and doxylamine-pyridoxine for mild or moderate symptoms (Cochrane).
Then the rule, in MedlinePlus's words: "Do not take any medicines for morning sickness without talking with your provider first" (MedlinePlus). The reason is bigger than nausea. Fewer than 10% of medicines approved since 1980 have enough information to determine their safety during pregnancy, because pregnant women are usually excluded from the studies (CDC). Your provider knows your history; a label doesn't.
Try today
The B6 ask
Time: 5 minutes
Write the question exactly: "Should I try vitamin B6 for nausea, and how much?" (MedlinePlus)
Under it, list what you've already tried: the snack clock, the ginger, the sips between meals. The answer will be better for it.
List everything you already take, prescription and over the counter, vitamins and herbal included. Talk to your providers before starting or stopping any of them (CDC).
Send it to the office today if they take messages, or put it at the top of the first-visit list.
Make it work:If a friend's bottle is already in your bathroom, leave it there until you've asked (MedlinePlus). Asking is a two-line message; it isn't a fuss.
Watch for
Normal
nausea that comes and goes through the day (NHS).
Call your provider
if you can't keep any fluids down for over 12 hours, lose more than 5 pounds (2.3 kilograms), feel lightheaded, or see blood in your vomit (MedlinePlus).
Normal
wanting to take what helped someone else.
Call your provider
before any medicine for nausea; that's MedlinePlus's rule (MedlinePlus), and the CDC's warning is that online "safe medicine" lists often lack sufficient scientific evidence (CDC).
Normal
tiredness and a few more trips to the bathroom (NHS).
Call 911
or go to an emergency room right away for severe chest pain or shortness of breath that does not go away (MedlinePlus).
Normal
a week of small plans and one unanswered question.
Call your provider
if you feel like something just isn't right, even if it isn't on any list, and tell every provider you see that you're pregnant (CDC).
For you
You're not alone in the question. About 9 in 10 women report taking some type of medicine during pregnancy (CDC). The hard part isn't needing something; it's the gap between needing it and knowing.
For that gap there's a free line. MotherToBaby gives free, confidential expert answers about medicines in pregnancy, in English or Spanish, by phone at 1-866-626-6847, chat, or email (CDC). It doesn't replace your provider, but it answers on a Sunday.
If you're the partner: your medicine cabinet is the other half of the question. Nothing of yours goes to her without the ask.
Sources
- NHS. "Week 6." Week-by-week guide to pregnancy, Best Start in Life. https://www.nhs.uk/best-start-in-life/pregnancy/week-by-week-guide-to-pregnancy/1st-trimester/week-6/
- MedlinePlus. "Morning sickness." National Library of Medicine, 2024. https://medlineplus.gov/ency/patientinstructions/000604.htm
- MedlinePlus. "Hyperemesis gravidarum." Medical Encyclopedia, National Library of Medicine. https://medlineplus.gov/ency/article/001499.htm
- Cochrane. "Interventions for nausea and vomiting in early pregnancy." Matthews et al., 2015. https://www.cochrane.org/evidence/CD007575_interventions-nausea-and-vomiting-early-pregnancy
- Centers for Disease Control and Prevention. "Medicine and Pregnancy: An Overview." https://www.cdc.gov/medicine-and-pregnancy/about/index.html
- MedlinePlus. "Common symptoms during pregnancy." National Library of Medicine. https://medlineplus.gov/ency/patientinstructions/000583.htm
- Centers for Disease Control and Prevention. "Urgent Maternal Warning Signs and Symptoms." HEAR HER campaign, 2024. https://www.cdc.gov/hearher/maternal-warning-signs/index.html
This guide is general education that summarizes published research and guidance from groups like the American Academy of Pediatrics, the CDC, and the WHO. It isn’t medical advice, and every child develops on their own timeline. Your pediatrician knows your child; if something feels wrong, call them. In an emergency, call 911.
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